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Velpanat is contraindicated to pregnancy condition due to concomitant use with ribavirin. Some anaphylactic reactions are acquired during the therapy, while the patients are contraindicated to the component of Velpanat.
Velpanat with st Johns wort causes losing the anti-viral activity of Velpanat by decreasing the concentration of either sofosbuvir or Velpatasvir. Velpanat combined with HMG CoA reductase inhibitors causes increasing the concentration of these drugs.
Velpanat co administered with acid reducing agents causes decreasing the effect of concentration of sofosbuvir & Velpatasvir leads to loss of activity of Velpanat.
Fetal damage condition is due to the concomitant use of Velpanat with ribavirin during pregnancy period.
Fatigue, Nausea, Asthenia, Insomnia, Irritability, Headache.
Velpanat tablets are combined with P-gp inducers either potent or moderate, causes loss of activity of Velpanat by decreasing the sofosbuvir plasma concentration.
DRUG SUMMERY
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